About Level Zero
Level Zero is pioneering next-generation biosensor technology for precise, real-time monitoring of critical endocrine biomarkers. Recognised as one of the top 20 startups across all categories worldwide at TechCrunch Disrupt 2024 - and backed by top-tier organisations like SOSV and Entrepreneur First - we’re pushing the boundaries of biochemistry and nanotechnology to revolutionize personalised health.

Founded by two seasoned engineers, we bring extensive experience in R&D, technical innovation, and commercial strategy to transform the way people monitor their health. Our mission is bold: to revolutionise health management by delivering clinical-grade data directly to individuals, wherever they are.

We’re seeking driven innovators to join us in pushing the boundaries of biosensing and health tech, making personalised health monitoring a reality for everyone. To achieve this ambitious vision, we’re assembling the best team in the world - dedicated to turning cutting-edge science into life-changing, real-world solutions.


About The Role
We are seeking a lead biosensor scientist to drive the development and commercialisation of our continuous aptamer sensor platform. The ideal candidate will have proven expertise in developing continuous monitoring devices for regulated healthcare applications, demonstrated experience transitioning research-stage sensors into manufacturing-ready products, and a track record working with in vivo validation studies and large-scale analytical verification programs.

This is a full-time, in-person role primarily based in London.

What You'll Do

• Lead the development and optimisation of electrochemical continuous sensor systems from bench concept through manufacturing readiness
• Design and execute large-scale analytical verification studies, including multi-parameter performance characterisation, stability assessments, and biocompatibility validation
• Oversee in vivo validation studies in human subjects and troubleshoot sensor performance in clinical settings
• Define manufacturing processes, material specifications, and quality control parameters aligned with regulatory expectations and QMS frameworks
• Engage directly with regulatory pathways (FDA, EMA) to define performance specifications and shape submission strategy
• Lead cross-functional efforts with electrochemistry, microfabrication, and manufacturing to translate designs into scalable production
• Develop technical documentation packages (CMC, analytical performance dossiers) for regulatory submissions and investor communications
• Mentor junior scientists and technicians in sensor characterisation and assay validation methodologies
  
  
  
  

What You Bring

• A Ph.D. degree in electrochemistry, materials science, biomedical engineering, or related discipline, with specific focus on electrochemical biosensors. Minimum 4 years of industry experience commercialising continuous monitoring or diagnostic sensor technologies
  
  
  
  

The ideal candidate will possess expertise in the following areas:

• Deep experience in electrochemical sensor development-particularly amperometric, potentiometric, or impedance-based platforms-with demonstrated progression from research concept to clinical or commercial application
• Proven track record managing regulatory submissions (FDA 510(k), De Novo, or CE marking) for continuous monitoring devices
• Strong experience designing and executing large-scale analytical verification studies including stability, accuracy, precision, and matrix interference assessments
• Demonstrated experience working with in vivo validation studies, including study design, data interpretation, and regulatory reporting
• Knowledge of manufacturing readiness, scale-up strategy, and GMP-compatible processes
• Proven ability to operate in QMS-ready environments with familiarity of ISO 13485, design controls, and regulatory compliance frameworks
• Understanding of biocompatibility, sterility, and shelf-life requirements for implantable or skin-worn continuous devices
• Proficiency in surface chemistry, material selection, and biointerface optimisation
• Expertise in aptamer-based biorecognition elements and aptamer optimisation for continuous monitoring applications
  
  
  
  

Nice to have:

• Experience with microneedle or transdermal ISF technologies
• Familiarity with SELEX or aptamer discovery workflows
• Experience with MEMS & electrode microfabrication processes
  
  
  
  

Who You Are
We value culture as much as we value technical expertise, creating an environment that’s equal parts collaboration, curiosity, and fun.

We’re a fast-paced, mission-driven young team on a quest to make a lasting impact, fueled by uncompromising integrity, unwavering support for one another, and the thrill of exploring uncharted territories. Our passion for excellence drives everything we do, and we welcome individuals who share our commitment to shaping the future.

If our vision excites you, here are the qualities we look for:

• You live and breathe integrity, tackling challenges with honesty and transparency
• You’re a self-starter who loves diving into the unknown, collaborating on complex problems, and taking full ownership of results
• You excel at open, clear communication and see every piece of feedback as a springboard for growth—especially in a science and data-focused environment
• You’re motivated by creating real impact, particularly when it comes to advancing human health
• You strike a balance between independence and collaboration, knowing when to seek support or invite others to join in
• You’re confident in defending your ideas, while also valuing respectful, constructive debate as a path to better solutions
• You thrive in the dynamic atmosphere of a startup, constantly evolving your skill set and fearlessly applying what you learn
  
  
  
  

What We Offer

• A full-time role with a competitive salary and equity options, reflecting our value in your expertise and potential
• An environment where you’ll collaborate directly with the founding team at a leading biosensor startup, gaining access to industry experts and thought leaders
• The chance to grow with us, including ample opportunities for leadership, career advancement, and exploration
• Travel to New York and other potential sites for R&D purposes
• The excitement of working on cutting-edge technology, shaping strategic decisions, and driving innovation at an early-stage venture alongside a superstar team
  
  
  
  

Be Part of Our Journey
If you're ready to be at the forefront of biosensing innovation and thrive in fast-paced, learning-rich environments, we'd love to hear from you.

If your skills and experience do not align perfectly with this role, yet you believe you have something unique to offer, we're keen to listen. Reach out to us with a short statement on how you can contribute and let's discuss where you might fit into our team.